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Consider earlier administration (3+ hours before bed) to allow cortisol-modulating effects to establish before sleep pressure builds
Oxytocin Modulation of Amygdala Functional Connectivity to Fearful Faces in Generalized Social Anxiety Disorder
This has been observed in clinical practice where 34% of patients co-prescribed metformin alongside PPIs were vitamin B 12 deficient, significantly greater than those on metformin (22%) or PPIs (26%) monotherapy, suggesting an additive effect
Vignoli et al
