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In a phase III study, known as COSMIC-312 (NCT03755791), which compared cabozantinib in combination with atezolizumab to sorafenib as a first-line therapy for advanced HCC, the combination therapy significantly improved PFS [142]

Abstract Since the introduction of insulin almost a century ago, more than 80 peptide drugs have reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis, multiple sclerosis, HIV infection and chronic pain

The supernatants were added to Rhotekin RBD-agarose bead followed by incubation at 4 C for 1 h with gentle agitation

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