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Similar content being viewed by others Introduction Antipsychotic drugs (APDs) are widely used worldwide to treat highly prevalent psychiatric illnesses including schizophrenia, bipolar disorder, and major depressive disorder 1,2

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Accordingly, diprenorphine is least soluble at slightly basic pH values, where neither group is ionized: increasing the pH beyond 9 results in deprotonation of the phenol, while decreasing the pH below 8 results in protonation of the amine (Figure 8)