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The researchers revealed that the mean patient-rated severity score associated with sputum production was decreased in the NAC group between visits 1 and 4 (P=0.08) in comparison to the controls, and none of the patients had to use any additional expectorant agents after receiving nebulization

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Although lysosomal pH and cathepsin B activity remained normal, morphological changes after Bafilomycin A1 treatment point to defects in autophagic lysosome reformation (ALR), a cellular process responsible for regenerating functional lysosomes following autophagy, further supporting the role of GDAP1 in PIK fyve -mediated lysosomal maturation

However, no motor impairments or other non-motor parkinsonian symptoms have been reported in PINK1 loss-of-function mouse models to date [29], [30]