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Similar mismatches have been described in the brain including regions of the dorsal striatum and prefrontal cortex which express high densities of 2 -adrenergic receptors despite a paucity of noradrenergic nerve terminals and low levels of extracellular NE
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Accordingly, EAE is most predictive for immunomodulatory and immuneCNS trafficking mechanisms, whereas remyelination-specific processes are often obscured by inflammation severity and axonal injury
If you're considering patches or other delivery mechanisms, ensure they're designed to deliver the ingredients efficiently
