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Description
While metformin and phenformin share similarities, phenformin exhibits certain characteristics that make it more potent than metformin: phenformin, with its terminal nitrogen atom substituted by a 2-phenylethyl group, is less polar and more lipid soluble than metformin

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These diseases are mainly represented by the congenital defects of urea cycle, classical organic acidurias, and the defects of mitochondrial fatty acids oxidation, with hyperammonemia being more severe and frequent in the first two groups mentioned
