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Description
Following conjugation, GSH-conjugated metabolites are exported via multidrug resistance-associated proteins (MRPs) and processed through the mercapturic acid pathway for renal excretion

250 The tumor microenvironment may be one of the culprits for therapeutic resistance, and researchers have found that maintaining or inhibiting the expression of certain molecules in the tumor microenvironment is a pathway for overcoming drug resistance

Ford ES, Giles WH, Mokdad AH

Available from: 10 May 2019] 14