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It is now understood that the number of repeats is positively correlated with earlier onset and disease severity, which worsens with time due to continual cell replication and diminishment of the FXN pool (Drr et al., 1996)
66,67 Although some observational data has linked daily coffee consumption with decreased incidence of tinnitus, other research suggests that, for modest coffee drinkers (those drinking about 510 ounces per day), reducing caffeine intake may reduce tinnitus severity

Ablation of the metal ion-induced endocytosis of the prion protein by disease-associated mutation of the octarepeat region

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