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"Vitamin B12 deficiency among adult diabetic patients in Uganda: relation to glycaemic control and haemoglobin concentration"
The risk is increased with concurrent use of hydrocodone bitartrate and acetaminophen tablets with alcohol and/or other CNS depressants

Sasaoka T, Ishiki M, Wada T, Hori H, Hirai H, Haruta T, Ishihara H, Kobayashi M (2001) Tyrosine phosphorylation-dependent and -independent role of Shc in the regulation of IGF-1-induced mitogenesis and glycogen synthesis

Any real decision to change dose on an investigational drug belongs with a licensed clinician, not a troubleshooting checklist
