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Hearts showed a high propensity for arrhythmias at the onset of reperfusion (Figure 6A), and hearts that were perfused with 4-ClDzp before ischemia showed significantly lower incidence of arrhythmias (Figure 6B)

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Another study reported that Cox17 specifically transfers copper ions to Sco1 and Cox11 during the assembly of cytochrome c oxidase (CCO), functioning as a key copper donor (50)