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Genetic fidelity One advantage that patient-derived organoids can have over patient-derived cell lines is their maintenance of genetic features observed in the parent tumor 12,40,90,109,110,111,112,113,114,115,116,117,119,120,122,125,127,128,129,130,131 (Table 3)

These disruptions have been found to impair communication in the MGBA, a pathway increasingly linked to psychiatric symptoms ( Figure 10 Although emerging evidence links xenobiotics, such as antibiotics (most commonly prescribed pharmaceuticals), glyphosate (most widely used herbicide), and microplastics (MPs)(ubiquitous emerging environmental contaminant) with anxiety and depression, studies remain limited and mechanisms of action are poorly understood (Zhang et al., 2021a

As granulomas mature, they develop fibrous walls and experience a significant decrease in the number of vessels penetrating the structure, which hampers the penetration of anti-TB drugs into the necrotic and hypoxic areas of the granuloma, where M.tb persists [98, 99]