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56 In the vasculature, endothelium-released NO diffuses into adjacent vascular smooth muscle cells and further leads to cGMP-dependent smooth muscle cell relaxation and vasodilation

Nevertheless, many peroxidase-like nanozymes also possess oxidase-like activity, such as V 2 O 5 22 , Co 3 O 4 23 , MnO 2 24 , CeO 2 25 , CuO 26 , Co 3 V 2 O 8 27 , Pt 28 , Pd@Ir 29 , Fe/Co-based metal-organic framework (Fe/Co-MOF) 30 , Au-MOF 31 , Pt-MOF 32 , and Prussian Blue 33

This metabolic adaptation not only facilitates the production of substantial ATP but also generates metabolites that are crucial for maintaining immune cell functionality (135)

Acetaminophen (Tylenol, Panadol, or in UK, paracetamol) destroys glutathione