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From the mechanism, iron accumulation in Tfh cells was regulated by the microRNA-21/3-hydroxybutyrate dehydrogenase-2 axis, which also strengthened the Fe (II)-dependent TET enzyme activity and demethylation of the BCL6 gene (119)
To better evaluate the impact of dietary regulation via the gut microbiota on host metabolism and the effectiveness of interventions targeting the gut microbiota in metabolic diseases, future endeavors should include systematic reviews and in-depth experimental studies
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