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In accordance with the latter report, phosphorylated ERK was decreased in EpCAM CRISPR/Cas9-mediated knockout cells, suggesting EpCAM augments integrin-mediated signaling [119]

Tryptophan metabolism in inflammaging: from biomarker to therapeutic target
It can lead to: Disrupts sphingolipid metabolism, which alters the intestinal cell membrane and reduces gut barrier function

doi: 10.1002/dmrr.1226 20 Pop-BusuiRBoultonAJFeldmanELBrilVFreemanRMalikRAet al
