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22 In line with the aforementioned findings regarding the capability of the ROCK inhibitor to prevent LA-induced responses, in both SkBr3 and Ishikawa cells LA promoted the formation of stress fibers in a ROCK-dependent manner as this effect was abrogated in the presence of its inhibitor (Figures 6a-f) that alone did not show any effects (data not shown)

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GCLC-KO mice showed activation of C1q, which triggers engulfment of neurons by microglia, and disease-associated-microglia (DAM), suggesting that activation of microglia is linked to the neuronal loss