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University of Pittsburgh School of Medicine researchers have developed an early-stage, experimental living eye drop that uses a naturally occurring eye bacterium to support corneal wound healing

[56] In heart failure [edit] In addition to atherosclerosis described above, specific epigenetic changes have been identified in the failing human heart

Notably, in peripheral blood mononuclear cells (PBMCs) from active CD patients, the upregulated hsa_circRNA_103124 enhances the expression of NLRP3 and GSDMD, key mediators of pyroptosis [82]