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According to the review, nano-co-delivery of natural products with chemotherapeutic agents is expected to be the basis of new tumor therapeutic strategies that facilitate the development and translation of anticancer drugs (256)

10.1038/s41467-021-26367-9 7

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Meanwhile, these mutated genes can alter the metabolic signaling pathways such as hypoxiainducible factor 1 (HIF1) pathway, regulate glycolysis and mitochondrial function, and thus increase the production of ROS [143]