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15 Being a powerful antioxidant, glutathione plays a critical role in several metabolic pathways: DNA and protein synthesis, amino acid transport, enzyme activation, immune system function, scavenging free radicals eg hydrogen peroxide, cofactor in Phase I cytochrome P450 enzyme-mediated detoxification, amino acid translocation across cell membranes, detoxification of xenobiotics, maintenance of sulfhydryl groups of proteins, mitochondrial function and maintenance of mitochondrial DNA, catalysis of exchange reactions and many more

3f and 6f), suggesting that increased oxygen availability, which may activate the TCA cycle to produce 2-OG, was not the main factor contributing to enhanced glutamate production in the 90 plate

By the end, you will understand the relationship between this vital molecule and environmental stressors

The cell pellets were collected by lysing cells with Radio Immunoprecipitation Assay (RIPA) buffer (Beyotime, P0013B) supplemented with protease inhibition cocktails, phosphatase inhibitors, and serine protease inhibitors AEBSF