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Some may also have a special test done on a skin sample or by DNA testing using a blood sample

Fumaric acid accumulation also inhibits the activity of adenylosuccinate lyase (ADSL) in the purine de novo synthesis pathway, resulting in an increase in succinylaminoimidazolecarboxamide ribose (SAICAR) and adenosine succinate, which can cause damage to the central nervous system [84]

Afkhami-Ardakani, M., Hasanzadeh, S., Shahrooz, R., Delirezh, N

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