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Our subsequent studies in human endothelial cells showed that the homocysteine metabolite, S-adenosylhomocysteine, a potent inhibitor of many methyltransferases, decreased tRNA Sec methylation to suppress GPx1 expression and activity [69]
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This study demonstrates that hepcidin regulates systemic iron homeostasis by binding ferroportin and inducing its internalization, thereby blocking the cellular egress of iron
