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Aspartate production by this route might under adverse conditions supplement the aspartate needed for transamination, when -ketoglutarate is converted to glutamate (Figures 3A,B)

That receptor-level mechanism is why dosage does not follow a simple linear dose-response curve and why higher doses do not produce proportionally greater fat loss

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Key words: Ergothioneine, Cardiometabolic disease, CVD, Type 2 diabetes, Non-alcoholic fatty liver disease Ergothioneine is a naturally occurring amino acid and thiol antioxidant found in high amounts in mushrooms and fermented foods