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However, recombinant proteins used were often devoid of the Fe-S cluster which is problematic because four cysteine residues now become possibly reactive and blur the conclusions

221,222 ROS directly impair insulin synthesis and secretion

Even if GPX4 was inhibited by RSL3, the ferroptosis phenotype was still effective under the context of GPX3 overexpression

[Abstract] Atenolol (ATN, 1 M, 48 h) reversed Norepinephrine (NE,10 M-induced alterations in the expression of SLC7A11, GPX4, and ACSL4 in TM4 cells
