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Description
Mechanistic studies reveal that acetyl-L-carnitine enhances cholinergic neurotransmission by increasing acetylcholine synthesis and release, upregulates nerve growth factor (NGF) expression, improves mitochondrial membrane potential and respiratory function in neurons, reduces oxidative damage to neural lipids and proteins, and modulates synaptic plasticity and neurotransmitter receptor function

Embodiment 203 The chimeric antigen receptor of embodiment 202, wherein said costimulatory signaling region comprises the intracellular domain of a costimulatory molecule selected from the group consisting of CD27, CD2S, 4- 1 BB, OX40, CD30, CD40, PD- 1, ICOS, lymphocyte function-associated antigen- 1 (LFA-1 ), CD2, CD7, LIGHT, KG2C, B7-H3, a ligand that specifically binds with CD83, and any combination thereof

Pain levels, functional capacity, subjective improvement feelings

doi: 10.1111/bph.14848
