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Description
Therefore, therapeutic strategies targeting intracellular regulatory environments may complement receptor-level interventions
Significantly, the A30P transgenic mice model made it possible to demonstrate that the compound can reduce the number of aggregates in the brain, thus ensuring target engagement [323]
Concordant observations were found in human lung cancer, where NSCLC patients with p53 truncating mutations had shorter OS with immunotherapy compared to patients with WT p53 expressing tumours [196]
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