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It was reported that the formation of hydroxylated metabolites on the 5-ethyl side chain and the 3-chlorophenypiperazine were major metabolic pathways of nefazodone in human liver microsomes

This was accompanied by a metabolic shift towards glycolysis and diminished mitochondrial fitness, characteristic of cellular senescence

Zinc- and copper-induced interleukin-6 release in primary cell cultures from rat heart