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The advancement of microfluidic co-culture models allows for an in-depth exploration of macrophage functions within the cardiac immune process, thereby providing novel insights for the development of therapeutic strategies for CHD (160)

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Moreover, animal and translational studies that suggest plausible neurodevelopmental effects at doses close to the therapeutic range were briefly mentioned in relation to biological plausibility, whereas recent experimental literature points to specific mechanistic hypotheses (e.g., CB1 modulation, OS, sexspecific prefrontal transcriptomic changes, epigenetic programming) deserve more neutral discussion (Philippot et al., 2018[86])

Activated casp-1 forms a heterodimer complex that catalyzes the maturation of IL-1 and IL-18 [321]