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The adopted approach allowed to identify a total of 40 clinical trials, of which 27 studies (67.5%) investigated the diagnostic potential of DNA methylation hotspots, while 13 studies (32.5%) focused on the methylation levels of cancer-related genes as prognostic biomarkers (Table 2)

Recent studies have shown that the RNA-binding protein RALY promotes OXPHOS activation and mitochondrial metabolic remodeling by regulating microRNA processing, thereby enhancing the adaptive capacity of CRC cells to EGFR or MEK inhibition [9]

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BPC-157, Body Protection Compound-157, is obtained from the parent protein Body Protection Compound (BPC)