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Consistent with the reduced in vitro binding, in TFG-depleted HEK293T cells reconstituted with exogenous TFG constructs, both PB1-deleted and CC-deleted TFG failed to support lysosomal CHMP4BmNG recruitment upon LLOMe treatment (Extended Data Fig

roseus , decreased the activity of leukemia cells while having considerably lesser cytotoxicity against normal human endothelium cells, showing that its activity was inhibited specifically toward leukemia cells (93)

Upon comparing control samples in the HEK-293 cell line with these incubated in a 0.1 mM H 2 O 2 solution, statistically significant differences in the levels of several metabolites were identified, including glutamate, acetate, pyroglutamine, glutamine, 3-hydroxybutyrate, lactate, and unknown_1

While effective for glycemic control and weight management, these mechanisms can limit nutrient intake and affect absorption