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Cuccioloni M, Bonfili L, Mozzicafreddo M, Cecarini V, Scuri S, Cocchioni M, Nabissi M, Santoni G, Eleuteri AM, Angeletti M (2016) Mangiferin blocks proliferation and induces apoptosis of breast cancer cells via suppression of the mevalonate pathway and by proteasome inhibition

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Close attention should be paid to potassium repletion, as low serum potassium will cause preferential reabsorption of potassium over hydrogen ions in the proximal tubule and compromise attempts to alkalinize the urine (26)

However, provided variations in the water content within the sample are much smaller than the variations in the metabolite levels, variance shared between normalized metabolite signals can be assumed to arise largely from shared variance in metabolite concentrations [52]