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Wang et al., 2018), or directly target the core clock and/or its output (Jepson et al., 2011

For some, it can affect concentration and memory, making it hard to stay focused
Subregions of CSD may be superior to CSD as therapeutic agents because they are easy to synthesize and likely to show improved tissue penetration and reduced side effects such as immunogenicity

ARC-9: a randomized study to evaluate etrumadenant based treatment combinations in previously treated metastatic colorectal cancer (mCRC)
