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Hydroquinone is the most commonly used depigmentation agent and is a first-line treatment for melasma

The Endocrine Society Guidelines recommend investigation in patients in whom Whipple's triad is fulfilled (58)

Safe practice usually comes down to a short list: Document every vial clearly: Record lot details, reconstitution date, and final concentration

While both drugs are effective, adding a third hormone (Glucagon) in Retatrutide brings a different side effect profile that researchers are still studying
