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The presence of an extra X chromosome (Klinefelter syndrome) or an extra Y chromosome, the presence of two X but no Y chromosome in a male, and microdeletions or translocations affecting the X or Y chromosome are examples of chromosomal problems that can disrupt sperm production and overall genital and gonad development, resulting in azoospermia (absence of sperm) and infertility

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Calculations : Mean intensity in the regions covered by collagen 1 or 3 was calculated from the masked images, generating an estimation of the amount of the specific extracellular matrix protein in each image
B12 may be injected into a muscle or beneath the skin at 100 mcg every day or alternate days for 7 days, and then every 3 or 4 days for a month