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GPX4 was a significant prognostic factor for OS and DFS on multivariate analysis at both 5% and 25% cutoff values
However, these proposed mechanisms, while potentially valid in specific contexts, may not fully account for NAC's therapeutic effects across all clinical applications, as the mechanism of action is not fully tested in some cases

Pharmacological Research 95 , 111-125 (2015)

10.1016/j.brainres.2015.03.018 [DOI] [PMC free article] [PubMed] [Google Scholar] Rossi R., Dalle-Donne I., Milzani A., Giustarini D
