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Introduction Recent proton magnetic resonance spectroscopy (MRS) studies in schizophrenia (SZ) have shown altered GABAergic ( In this study, GABA, glutamate (Glu), glutamine (Gln), lactate, and the ratio of Gln/Glu were quantified from five brain regions [anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), centrum semiovale (CSO), thalamus (Thal), and hippocampus (HP)] in each of the three groups: participants with schizophrenia (SZ), first-degree relatives (FDR), and healthy controls (HC)