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Results Inhibition of CD38 NADase by Ab68 treatment ameliorates skin and lung fibrosis Homeostasis of NAD + is governed by the action of the CD38 ecto-enzyme together with NNMT, which catalyzes the methylation of nicotinamide (NAM) generated via CD38 (Fig

50 Studies have shown that in the mouse model of knockedout SLC38A3 activity, associated perivascular astrocytes showed swelling and a decrease in the apparent diffusion coefficient

For all assays, the intra-assay CV (coefficient of variation) and the interassay CV were typically below 5 and 13%, respectively unless indicated otherwise

doi: 10.1111/j.1462-5822.2004.00376.x 38 BrandtzaegP.BrynK.KierulfP.OvstebR.NamorkE.AaseB.et al