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Choline can be generated from phosphatidylcholine via phospholipases or converted to phosphatidylcholine via the cytidine diphospho-choline pathway (see Figure 2a)
In addition to genetic susceptibility, increasing evidence suggests that environmental factorsincluding prenatal exposures, dietary patterns, gut microbial alterations, and metabolic stressorscontribute to ASD prevalence and phenotypic heterogeneity
doi: 10.1097/HPC.0000000000000236 Whittle JS, Pavlov I, Sacchetti AD, Atwood C, Rosenberg MS
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