isothiocyanate glutathione A Comparative Review of Key Isothiocyanates and Their Health Benefits Isothiocyanates in medicine: A comprehensive

Key search concepts included *Ganoderma lucidum* polysaccharides, diabetes mellitus, inflammatory responses, programmed cell death (apoptosis), insulin resistance and sensitivity, oxidative damage, pancreatic islet function, glycolipid homeostasis, gut microbiota modulation, multimodal or integrative therapies, structural or formulation advancements, diabetic nephropathy, hepatotoxicity, cardiovascular complications, chronic non-healing diabetic ulcers, neurodegenerative and neuropathic manifestations, and diabetic retinopathy

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PAR-1-knockout mice treated with a subpressor dose of Ang II for 4 weeks failed to cause vascular remodeling of the aorta but did induce cardiac hypertrophy, in contrast to the effect on wild-type mice, indicating that PAR-1 plays a significant role in vascular remodeling induced by Ang II without raising blood pressure

Crooker K, Aliani R, Ananth M, Arnold L, Anant S, Thomas SM