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Exposure to ROS dissociated Nrf2 from Keap1 and allowed relocation of Nrf2 to the nucleus, where ARE responsive genes became actively transcribed
Tranexamic acid has the best evidence for treating melasma, however it is a thrombophilic drug and thus should be prescribed in select patients

Alterations in monoamine neurotransmitters and dendritic spine densities at the medial preoptic area after sleep deprivation
