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Under normal mitochondrial homeostasis, anti-apoptotic members of the BCL-2 family, such as BCL-2 and BCL-xL, are anchored in the outer mitochondrial membrane
Together, these data show that FOXO4-DRI potently and selectively reduces the viability of senescent cells by competing with FOXO4-p53 binding, thereby triggering release of active p53 to the cytosol and inducing cell-intrinsic apoptosis through Caspase-3/7
M., Kandemir, H., Shah, S
Otto, O
