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Fibrates decrease APOC2 gene expression through peroxisome proliferator-activated receptor (PPAR) 65 , whereas PPAR coactivator 1 (PGC-1) partners with HNF4 to increase hepatic APOC2 mRNA levels under fasting conditions 68

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Some patients harbor bacterial populations that are more efficient at producing hydrogen sulfide from sulfur-containing substrates, making them more prone to this side effect regardless of other risk factors