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Increases in GSSG relative to GSH are a useful indicator of oxidative stress or disulfide stress (slund and Beckwith, 1999), and in plants can be observed in response to conditions such as ozone, pathogens, and cold, as well as deficiency in important H 2 O 2 -metabolizing enzymes such as catalase and ascorbate peroxidase (APX

Stockmann et al., 2025), with motor symptoms being especially affected (Kotagal et al., 2013)

9 ), another plant-derived compound, has been investigated for its ability to traverse the blood-brain barrier (BBB)

doi: 10.3389/fendo.2022.1015520 30 De RosaMZarrilliSDi SarnoAMilanoNGaccioneMBoggiaBet al