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Description
This gap partly stems from the traditional reliance on larval models for speed, leaving adult zebrafish underutilized for studies of chronic exposure, cumulative toxicity, and long-term therapeutic efficacy (White and Patton, 2023)

That is, the difference between the 5-km times on different weeks for the same subject is expected to be less than 2.77 times the within-subject standard deviation for 95% of pairs of observations [26]
10.1056/NEJMoa1509225 49

Across the functional groups most relevant to biochemistry, pKa values span an enormous range: from approximately 8 for HCl, through 5 for carboxylic acids, 7 for imidazoles, and 10 for thiols, phenols, and protonated amines, to 35 for amines and 50 for alkanes
