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A study [4] indicated that glutathione and glutathione transferase are located mainly in the cytosol fraction of animal tissues and the enzyme activity is generally greater in hepatic than extra hepatic tissues

However, both control animals as well as folate-deficient animals treated with aspartame for 90 days showed significant decrease in IL-2, TNF-, and IFN-, and an increase in IL-4 level, when compared to control as well as folate-deficient fed animals

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