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The prevention of these processes in Protandim -supplemented mice presumably accounts for most if not all of the increased PON1 activity

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This activates the AMPK/Peroxisome proliferator-activated receptor coactivator 1-(PGC-1) pathway, restores disrupted fatty acid metabolism in cardiomyocytes, maintains mitochondrial energy homeostasis, and suppresses myocardial fibrosis and hypertrophy
