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162,163 In a randomized placebo-controlled trial in 100 women with menopausal symptoms, treatment with a traditional formulation of dong quai plus astragalus for six months led to a significant reduction in mild hot flashes, but no other improvements in menopausal symptoms, relative to placebo

Therefore, pairing copper with niacinamide appears relevant, as niacinamide helps protect the skin barrier and defends the skin against oxidative stress

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