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This does not mean every elevated SAH result proves toxicity. It means toxic and inflammatory burden should be considered when methylation support fails, symptoms worsen with methyl donors, glutathione demand is high, or the patient has mold, chemical, gastrointestinal, renal or mitochondrial clues

Statistical analysis All outcomes except body mass were analyzed using two-way analysis of variance (ANOVA) with group and age specified as between-subjects factors

doi: 10.1016/j.ynpai.2022.100091, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 44.van Hameren G, Muradov J, Minarik A, Aboghazleh R, Orr S, Cort S, et al