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[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Ramirez-Tortosa M.C., Ramirez-Tortosa C.L., Mesa M.D., Granados S., Gil ., Quiles J.L

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Figure 3 3.2 Copper-induced cellular necrosis Cellular necrosis represents another form of cell death, characterized by the disruption of normal cellular metabolism due to various causes, leading to morphological alterations and culminating in cell lysis and destruction, a process known as necrosis ( As previously mentioned, copper can participate in redox reactions, generating reactive oxygen species (ROS), such as superoxide and hydroxyl radicals ( 3.3 Copper-induced cellular autophagy Copper-induced autophagy is an intricate biological mechanism, whereby cells stimulate an autophagic response to counteract excessive internal copper

15 In addition to TQ, black cumin seeds contain thymoquinones and flavonoids