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In DOR, the decline in follicle number reduces estradiol and inhibin B secretion, thereby altering GnRH pulsatility and the LH/FSH ratio, which impairs corpus luteum formation and predisposes to luteal insufficiency [31]

2013 Jan 17;4(1):e461

Importantly, NRF2 activation has been shown to alleviate PD-associated pathological hallmarks, specifically oxidative stress, mitochondrial dysfunction and neuroinflammation through expression of its target genes (Yang et al., 2022)

The mechanism involves modulating stress-induced gut inflammation and reducing plasma LPS levels, thereby influencing brain TLR4 signaling pathways