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These treatments are expensive (over $50K pa) and generally useless and include Chelation therapy, Graded exercise therapy guided by exercise physiologists Cognitive behavioural therapy guided by clinical psychologists Treatment of sleep disorders - by a sleep consultant Treatment of depression, by a clinical psychiatrist, generally with the use of SSRIs, or SNRIs or other addictive anti-depressants

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Additionally, treatment of DIO mice with the NNMT inhibitor resulted in a substantial 35% decrease (P 30% decrease in adipocyte size (P 40% decrease in adipocyte volume (data not shown) compared to control DIO mice
