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To visualize small-molecule metabolites localized within TLS, we used matrix-assisted laser desorption/ionization time of flight imaging mass spectrometry and found significant accumulation of glutathione (reduced form: glutathione [GSH], oxidized form: glutathione disulfide [GSSG]) within TLS (Figure 1C)

This makes them more likely to have a Vitamin B12 deficiency and thrombocytopenia

In a murine model of colitis, curcumin was able to normalize the expression of autophagy-associated genes (Beclin-1, LC-3II, autophagy-related 5ATG5, B cell lymphoma 2BCL-2), leading to disease improvement

Currently, attempts to adapt consumer-grade wearable activity trackers and mobile technologies at a low cost instead of using conventional actigraphy are increasing, thereby enabling the construction of a population-based rest-activity cycle database